+1 for Altium in a Windows 7 64-bit VM under Parallels 9 running on top of Mavericks. Works just great.
It works well running in a large window or full-screen rather than coherence or modality. I give the VM 4G RAM and 2 cores, but it ran fine on my older Macbook Pro (2009, core 2 duo) with 3G and 1 core. The 3D rendering was fine on a 2009 MBP (2.8 GHz Core 2 Duo, 8 GB RAM) a 2008 Mac Pro (2 x 2.8 GHz Quad-core Xeon + 24GB RAM), and on a new (to me) 2012 MBP (2.7GHz i7 quad core + 16GB RAM).
I had been using the mini wireless KB, but finally switched to a Logitech solar wireless. Mouse is a Logitech Performance MX. 3D mouse is a SpaceMouse Wireless. I take a 3D mouse even when traveling if I plan to use any CAD software. The desktop uses a 30" DELL monitor. With the 30", I think there is plenty of real estate for CAD work, including side-by-side documents, cross-probing, etc. The main impetus for another monitor, IMO, would be perhaps pulling up mac OS apps such as Emacs to edit verilog or firmware source while viewing the circuit full screen in the VM.
I have used VMWare on Linux before I switched to a mac, and continued using VMWare until I moved from Eagle to Altium in 2009. At that time, Parallels was *much* faster for 3D rendering than VMWare, but it's been a long time, and I'd be surprised if VMWare hasn't caught up.
Dave