The 8220 will handle single supply as long as you
meet the common mode allowed input voltage range
for the single supply use. There are graphs covering
this in datasheet, and specs.
Page 13, 14....
http://www.analog.com/media/en/technical-documentation/data-sheets/AD8220.pdfAs an aside PSOC 5LP UP can handle this with its 20 bit differential A/D and input
rail to rail capability. Again as long as common mode put out by the sensor
meets its allowed range. Plus you get a digital filter should you need to post
process the sensor signal path. This shows single ended example, differential
mode a trivial setting. This is all onchip + reference + arm core + a whole lot
more. In fact the PSOC A/D will common mode outside its supply rails by 100
mV, not much but solves many application problems, like high side sense for
example.
Regards, Dana.