Based on my experience - splitting the 0V is the wrong thing to do unless you have safety issues or you REALLY know what you are doing.
Remember, current flows in a loop. I have seen (and had to fix EMC problems on) too many boards where people have followed the "one 0V for analog, one for digital" route and got it wrong. In almost all the cases - having a single 0V plane in the PCB fixed the problems. The common issue I found was that people used one power rail for the signal into an op amp, and a different rail for the power supplies for that op amp thereby creating many loops of current around the board.
I have also seen boards that work on measuring very low currents (<1pA) that did not have a split 0V.