If the chopper transistor of a simple buck converter fails it *WILL* take out your load.
If its got to tolerate 100V in, you'll need something with significantly over a 100V max rating.
I'd look as single chip flyback SMPSU controllers with integrated chopper transistors. As long as the minimum UVLO threshold is under 40V and you derate the output power according to the ratio of the actual input voltage to the normal application supply voltage, it should work out OK. It will require a custom wound transformer though, with windings for the 5v supply and whatever you need for the analog stuff.