The control loop in a regulator needs to look at the
load voltage with respect to a known reference,
to measure it in order to control it. All of which
has to have a know potential, which has to be
measured between two potentials, one of which is
ground. Think of using a voltmeter, you measure
by placing red probe on the voltage you want to
measure, and the black where you want the
measurement to refer to.
Potential, voltage, is always measured relative to another
potential, most commonly ground in the electronics
sense. There are other measurements where you do them
differentially and the ground is not necessarily used. Like
measuring the drop across a R that has no lead connected
to ground.
Regards, Dana.