It's not impossible, but you might look at how it was done with the EDID I2C data lines for VGA monitors. However, these only had an I2C prom at 1 side, ran at 1kHz or less, had check-sums since the reads were error prone and had to be done multiple times, both the analog signals had their own shielding + the larger cable housing everything else also had a second frame ground shielding, there was heavy cap filtering at the ends + the I2C prom was also powered through the same cable as well. It wasn't too reliable a system especially when some monitor extension cables sucked, or, some video cards attempted to run the thing at 3.3v instead of the full 5v.
I got lucky with a functional 12meter extension cable, still being able to read the EDID on my video scaler.