That board looks pretty good as long as its input side is either properly grounded, or *everything* connected to the input side is in an insulated enclosure with no user-accessible connectors or metal parts. The key features that makes it fit for purpose are those slots round the relay common pins that provide enough creepage distance and clearance for use at 125V AC,and the fact its got proper mounting points. I'm not sure I'd trust it at the relay's full rating of 250V AC, as they've screwed up the track placing and reduced the clearance distance between the common pin and the coil connections - its *PROBABLY* OK, but you'd need to do a Hi-Pot test to be reasonably certain. Also, use Nylon mounting screws for the holes next to the relays, and plastic spacers. I'm *NOT* happy with the clearances if you used metal ones.
As usual they've screwed up the optoisolation on the input side. Without it, it solely relies on the coil to contact isolation of the relays. How did they screw up? Well, the rule of thumb there is 'Preserve all the isolation distance the width of the optocoupler gives you', which means you *DO* *NOT* run tracks under it, and maintain a clearance barrier equal to its body width between all tracks that are part of its input side circuit and all tracks that are part of its output side circuit. e.g. That ground plane under the optos shouldn't be there or at least should have a 0.3" gap in it running right across the board under the optos, completely free of copper. However it looks like there may potentially be effective low voltage isolation - enough to stand off 50V DC max between the circuit powering the relay coils and the controller driving the inputs. Some testing and circuit tracing would be required to determine if there is any isolation.
If this is going to be a fixed installation, be aware that using that relay board for controlling mains loads is almost certainly not to code and will probably fail inspection.
Also I wouldn't trust the relays current rating. As usual with cheap Chinese electronics, halving the nominal current rating is a good starting point.
If you want to do it right for a fixed installation, use chassis mount (or DIN rail mount) UL rated screw terminal relays, and a separate driver board. All wiring needs to be secured so the coil and mains circuits cannot come into contact with each other even if the wires come loose from the relay terminals, and there should be a grounded metal or insulating partition between the low voltage boards (i.e relay drive board and controller) and the mains wiring. The coil control circuits should be run through the partition using double insulated wire, with grommets in the holes to prevent abrasion. If a low voltage PSU is required, use a UL approved bell transformer or PSU, intended for fixed installations, not a phone charger or other wallwart.