Well, my design involved 8x microcontrollers doing four PWM channels a pop and nothing else, and one larger chip to potentially do more fancy stuff - maximum power limiting, gamma correction, color temperature calibration, fades, mixing, etc. Since the PWM micros don't do anything but listen for new values, there would be little to no need to reprogram them. I'd be doing the loading, since I'd need to test the boards anyway.
Wiring: Well, if you used a 240W power limit, the wires between the dimmer and the PSU would see 20 amps. So I'd suggest 2.5mm
2 or above. Normal insulated copper wire is fine. The wires to the tiles can be 0.5mm
2 as mentioned before.
Sagging: I just modeled it in Solidworks, because it's quick and easy. 2mm would be worse, but not shockingly much so.
Back side reflection: You will need to use a white reflector. I accidentally found some
white film - the kind used in professional units as backing "paper". $136 for a 1x30m roll. Spray glue that onto some MDF or something. $2.26/tile, so not
super cheap, but it beats paint or printer paper...
Front side diffusion: I remembered that Rosco does diffusion films; while it certainly is not going to be the cheapest option, I did find 1.2m by 7.62m rolls for $93, or $3.8/tile. I'd imagine you could find better deals on this sort of thing though. I did also find pre-made 2mm diffuser sheets (these would not do anything as a light guide) at around $10/pop for 60x60cm sheets. For experimenting, I suggest finding a suitably sized broken LCD TV; it will have all the relevant films inside the panel.
Evenness: Any issues will show up as the edges of the tile being brighter than the center. Worst case you will see the individual LEDs shine through. Also, just plain flat acrylic is not going to do very much on its own.
Also, you may want to take a look at the suppliers
here - the minimum orders are hilarious, but there may be suppliers willing to work with you. Also, for pricing it, you need to look at 100+ unit pricing to get a realistic idea, given that you're making a lot of units.
Lastly, just checked and I paid $35/pop for my Lumin panels (
30x30 cm, 4200k, including a fancy driver - probably $20-$25 without it). I'd expect the price to drop 30% or more if you placed an order for 100 panels.
Edit: Just found
these LED strips, with all four colors in one LED package. Would make diffusing it easier, plus they make 24V versions, which is substantially nicer to work with.