Sounds reasonable to me. I would definitely use separate GND return paths at this current level, I assume that you are going to split it into power GND layer 3, and signal GND at layer 1. Plus one star connection between the two. You may still have ground shift problems with signals going to the connected loads, maybe use differential signaling, or add a separate signal GND going to them, plus level shifters. Add as much filtering as possible at the power outlets when possible, at least some MLCC, to decouple noise generated by the connected loads.
The transceiver should have good supply filtering, otherwise something may couple into the baseband signals. I would not be too much concerned about direct coupling to RF from the power rails, unless you have some very noising switching action.