There are those pre-drilled PCB stripboards with the rows of 5 holes connected together with copper.
Otherwise, dead-bug/point-to-point construction.
If you want custom PCB, you will have to etch. I don't see etching as taking up much space... FeCl3 is just messy.
As for holes, you can get a mini tabletop drill press, like an 8-inch unit, that maybe you can C-clamp to your table when you use it. Actually, for light PCB drilling, you probably won't need to fix the base at all.
If you don't want to drill holes, then you're into SMT stuff, but that's finer pitch, so your home etching technique will have to be well honed... Besides, you probably need to drill holes for wires.