There are very few, rather special ways to measure a voltage without a common ground or a some way defined relation. So even if the input is differential, one would need a defined DC level as there will be a limited common mode range. Without any ground connection it would be more like battery powered amplifier and ADC and sending the data via fiber.
For the input there are two choices:
1) A high impedance divider at the signal followed be a kind of buffer. Here input impedance is kind of a compromise between loading the source and noise. So the divider might be at 10 M, 20 M or so. For a differential input there would be two dividers, limiting the common mode suppression.
2) One or two (for differential) special high voltage buffers for the input signal(s). A divider would than be after the input buffers and can be lower impedance, though there are still limits due to self heating and thus nonlinearity. So the divider impedance might still be in the MOhms range. In case of a relatively large common mode voltage and small differential signal one might prefer a special high voltage instrumentation amplifier (e.g. build from discrete transistors / FETs) instead of the buffers.
Chances are that you don't need such a good ADC after the amplifier.