If you're working with a small capacitance - say 2.2nF, or 100nF - then it's easy to get 50V capacitors cheaply, even in an 0603 package, and you can just specify 50V for all those capacitors without really thinking about it.
But if you wanted to go to a significantly larger capacitance - say 2.2uF, or 10uF - then you're much more limited in the tradeoffs you have to make. The capacitors are often much more expensive, the dielectrics are often a less well behaved class, and the voltage ratings are often significantly lower, say 10V or 16V, especially if you want to stay in the 0603 package. So then you have to start thinking about harder choices - being less generous with the voltage rating, how much margin you need, how the dielectric behaves under voltage and how much capacitance you really need, how much you're willing to pay for the capacitors, and whether you're able to move to a larger package footprint.