A good reference for this issue might be the Philipinnes, as for historical reasons they use 220V 60Hz power, but neither wire is close to ground. The power is actually +-110V, so its like the US 220V arrangement, but every appliance in the house runs on that phase split 220V 60Hz power. So, you see a far broader range of appliances being run from split phase power than you do in the US.
Most plug in appliances sold in the Philipinnes are the same as the appliance sold in other 220V markets, with just the mains plug selected for local use. A few 220V 50Hz appliances don't like the 60Hz power, so a special version might be need. Typically, the Korean (also 220V 60Hz, but with the two wires being live and neutral) version of the appliance is OK for the Philipinnes. In some cases where the appliance is designed to be wired in it will have been designed with an assumption about the live and neutral inlets always being the right way around. There might then be issues with the assumptions made in the appliance's design. I have experienced this with a large UPS and some large computer and telecoms equipment. Either a specially adapted version was supplied, or an isolation transformer was supplied by the vendor.
So, the bottom line is a few appliances need to specially allow for split phase 220V 60Hz power, but mostly a piece of European 220V 50Hz equipment works just fine.