A practical example.
I have on my bench at the moment a phased locked loop that covers 35 MHz to 75 MHz in 0.1 Hz steps. The VCO sensitivity is 3.5 MHz/V or (and this is where it gets interesting) 3.5 Hz per microvolt. So, if I change from 40.0000001 MHz to 40.0 MHz the VCO voltage has just dropped 29 nV, not a lot. If the 3.3V control logic was sharing the same groundplane*** as the VCO the switching noise would modulate the VCO input and I would not have a very good synthesizer.
*** Note that no groundplane is perfect, it has inductance and resistance and therefore has circulating currents.