@ Dave:
Don't forget the human factors.
The planes have many system redundancies, but the captain may not have been in the cockpit at the time of the incident. The first officer had just transferred on the B-777. This was his first big jet and he was a rookie.
A real explosive depressurization is very stressful. Noise, wind, cold and thick mist making it difficult to see anything in the cockpit. At 35,000ft, they had 10-15 seconds to fit their O2 masks, assuming the O2 system was not damaged.
The crew of the Air France A-330 lost control of the aircraft, but it was airborne for about 5 minutes before it hit the water and they never had time for a mayday call.
The area is full of waypoints and airways and primary radars are not precise at long range. It could be just a coincidence.
An inflight hi-jack is not impossible, but very difficult nowadays, with a protected cockpit door.
A rogue suicidal crewmember is a possibility, but it has its problems too. A pilot wouldn't climb his airplane above max certified ceiling from 35,000ft to 45,000ft, as radar plot analysis conveys. Then why fly for 5-6 hours before crashing into the sea, assuming the southern route is the more plausible one (too many radars on the northern track). So far, there is also no real evidence of unstable personalities among the crew.
All very mysterious so far, with no simple explanation yet.