I suspect she would be overjoyed to get out of the city a bit. She would be able to afford more space, have a garden, get some sunshine, not worry so much about parking, crime, etc.
Suburban areas outside of large cities may no longer be as hostile to non-traditional people as she might remember from her past, if she grew up in some non-urban area.
She should move because the longer she stays, the more time recovery (as far as her health) from the current situation could take, I suspect.
If I were her, though, I would save money- if she buys a place, she should only buy right after the next crash, which seem to occur almost like clockwork every ten years or so. And not get a variable rate mortgage, or ideally, any mortgage. There are communities where people can buy houses for very little. Big parts of the country cost very little to live in, unlike the Northeast or West Coast. Finding one that also is a positive place that wont be hostile to her being trans, seems like a big job but it would be made a lot simpler if she finds people who have successfully made similar transitions and gets advice from them. They must be out there somewhere.
Todays nice affordable small town often becomes tomorrows unaffordable small town so its a moving target.
At one point in my life I was considering moving to the area around Santa Fe, NM, in the US Southwest, because I really like the food, artistic, tech and social matrix, and awesome scenery and hiking around there. And at the time it was really cheap. Not any more! Now its just insanely expensive. People have to act on things like that when they can.