I use Digi-Key first, then Mouser, Newark and Allied, and also sometimes check Avnet and Arrow. I have open accounts at Digi-Key, Mouser, Newark and Allied. I also buy some connectors from a NON-stocking distributor. Their prices are HALF of the others, but everything comes from China or something, usually 8 - 12 weeks. But, it is worth it to get 50% off on 50 - 100 connectors of each type.
It just doesn't make sense to fret over small differences on a reel of resistors, the saving of combining shipping into just one order makes up for it.
But, when talking about several hundred chips, power transistors, or whatever, then it makes sense to check several distributors.
Recently I had to order a Pulse Engineering inductor, it was surface mount, so that was the only part that would fit the PCB lands. Nobody in the US had them, but Arrow had them in the Netherlands. Surprise, they were SIGNIFICANTLY cheaper than any other distributor, and Arrow covered all the shipping, too! I'll have to check with them more often on stuff!
Jon