I used a local company, BEC for over 20 years. They let me fill ANY size panel with however many designs I wanted, with NO extra charges.
The ONLY extras was #holes, which was fair, and really bugger all extra. A few other local manufacturers relented and used to charge ~$15 for each extra
design per panel, and I was fine with that too. BUT, most locals have gone now (and not just because of that).
In my case, I had many tiny pcbs / fillers / adapters that would incur $200+ setup cost for EACH one ! Absolutely not worth it !
They told me that, they made very good money charging each person a setup cost, then cramming as many "prototypes" as possible on a panel.
They made more this way than a production run, for far less cost and effort. I still haven't found a "reasonable" supplier, I don't care if they limit it
to 3-5 designs max for a small increase. It's a PITA
Edit: ~30 yrs ago, when a panel here cost anywhere from $1,000-$2,000, making a "single" PCB with GND and VCC tracks linking them was a common trick.
The bastids would still cut them up and charge extras ! There'd often be arguments as to whether it was a single PCB or not. I'd often have to supply a circuit
diagram et :-) but I'd get crafty with that too !!