1: The pink line. Include the layer in Gerber set and include a note to the manufacturer about the layer that has the board edges. Btw, the usual layer for the edge is the keepout layer. no matter, you still need to send the Gerber data and the note.
2: Yes, and no, assuming the pads are big enough. For multilayer, you add a layer pair. I'm not on the computer I have Altium so I'm guessing, but it might be in board properties. A four layer PCB for this project is a bit overkill.
3: Put it in the bottom left corner, so all coordinates are positive. It should not really matter, but five seconds to avoid any potential problems is worth it.