So far my AVR ISP mkII clone gave me no issues. I am using Windows 10 Pro amd64 on a Gigabyte GA-Z97M-D3H motherboard with a (slightly) overclocked Intel Xeon E3-1231v3 processor. If you are seeking replacing the ISP you might as well upgrade to the Atmel ICE (no issue on my computer too) which can not only program but also debug your MCU. And if you don't mind spending the time you can create a serial bootloader that speaks STK500v2, so you can skip the ISP entirely except on a fresh board.