Thanks Tom
The same datasheet shows above that, that the full scale differential input is +-2.048/PGA
The isolated input doesn't have the the -Ve input connected to the supply ground so this one can actually measure the -2V to +2V input from the sig gen. Thankfully this is the one I needed pos a neg inputs on and can live with the 0-5V input.
It tripped me up as I have used other ADC's where I can do this but like you mention, the -REF is connected to a negative reference. The MCP3428 does not have any ref pins, it's all internal.