You mean beside the shielded part of the module?
Sure, no problem. In fact that should all be ground plane surrounding that thing, anyway. (You put ground plane / pour on your boards, right?...)
Keep everything away from the antenna end, especially signal traces and ground pour. You usually want a keepout on the board in that region. The datasheet probably talks about this.
If you're concerned about HF coupling into things, you can add a few extra pF to most any signal trace without too much worry. The resonator probably needs some explicitly, or already is a capacitor (among other things).
If you aren't concerned about HF coupling into things, consider that most CMOS inputs are high impedance (especially around low power clock oscillators!), and you can end up with weird glitches and extra transitions and mysterious DC offsets or transient weirdness (since BT isn't continuous wave after all, but goes on and off!).
Bipolar amplifiers are especially prone to detecting (rectifying and making a DC offset from) signals well beyond their bandwidth -- for example, a little 100kHz ripple will already cause an LM358 to behave slightly odd (not quite correct at DC), even though that's still well within its GBW; interference in the MHz+ range is actively detected and rectified by the front end transistors (which are just diodes, first and foremost). Not sure if it will do anything with 2.45GHz, but GSM cell phones are notorious for pumping noise into everything, and that's 900MHz+.
Tim