Anything involving high speed digital or RF (which high speed digital basically is) is very tricky to design, esp if you are using tools like eagle etc. Even Altium Designer is not up to analysis of these circuits...
Things come into play at high frequency like the substrate (ie standard Double sided boards are Fibreglass FR4) thickness of substrate, plating thickness and type of plating, thickness of copper.....
I am taking it that you are using an RF module, if you keep the distances from the module to the RF IO connectors as short as possible this helps... Also remember that traces at these frequencies act like mini antennas etc. etc.
Just some things to think about oh also remember to go to the manufacturers website, they will have lots of appnotes that will show recomended PCB layouts, Substrate materials and thicknesses etc.
HTH