You haven't given any dimensions (that I can see). You just need to be sure you satisfy creepage and clearance requirements for the environment the board is going into.
7mm distance should be both easy to achieve and ok, but if you look up the requirements you probably get away with less.
One thing I will say is the size of the cutout near F1 (left centre) will make the board unnecessarily weak. That area near the centre tap on the primaries looks very weak.
Not even sure if you need that cut out anyway?
You need to maintain high isolation ~4000V between primary and secondary but not between active and neutral.
IMO You probably only need the big slot in the centre about 3-4mm with rounded ends. Slots with rounded ends will be stronger.
Maybe bring the corner posts in a smidge too.
What are you using for terminals? I would use properly rated ones on the primary at least.
Silk screen the Active, and Neutral and what about earth? Might be nice to have one there in case you have a three wire lead.
Sorry 3 replies beat me to it.