I just spent about 4 hours trying to get this to work :/ until I noticed the GND pin of the SOT23-6 wasn't very well soldered.

With poor ground:
- Vadj > 1.2V (follows output voltage) which is WRONG...
- Switches infrequently, probably due to bias current flowing through FB pin.
- Draws about 100uA~200uA.
Anyway, that is now sorted...!
Things I have learned:The MCP1640
will not start into heavy load. It will start into about 5.1V/150mA. However, it will not start into 5.1V/300mA. It will do a few cycles then give up with low output voltage, this is a latching condition which will only reset once power is fully cycled (Vin < 0.6V.) Once running, it will happily accept additional load with no problem. This isn't a problem for my application, but was a little confusing at first. I do need the 300mA, but that can be switched on or off, with a high side P-FET.
It will give 5.1V@300mA down to about 2.8V, which is pretty close to the minimum cut off for a li-ion cell. With no load, it will start from about 0.63V, and work down to 0.5V, giving 5.05V out.
The datasheet shows only DFN-10 package being used for 5V,300mA application; with a 10uH inductor. I'm using SOT23-6 and a 4.7uH inductor. Presumably this is a thermal thing or maybe peak current related. But, I have run it for over 10min with this load, and it only rose 15 deg above ambient. I can touch it with no risk of burnt fingers. It shows no signs of problems with this kind of load.
I intend to run a Noritake Itron GU112X16G-7002 graphical VFD from this, along with a TI ARM (Tiva MCU, TM4C123G) processor. In total, the load shouldn't exceed about 270mA with all running, less if the VFD is dimmed or displaying less bright pixels (though this only varies power usage by about 10%, or 20% if you use the dimming feature.) It will all run from a single 18650 li-ion cell, 2000mAh known capacity.
I'm unable to get the low standby power the IC advertises :/. I can get down to about 0.3mA at no load at 4.2V in, increasing to around 0.6mA with 3V in. I figure this might be due to my poor layout. It's probably switching too frequently, perhaps due to feedback pin pick up. This will only give about a year's standby usage. I was trying to target around 50uA, which should be about the self-discharge rate of the li-ion, which would put me closer to 5 or 6 years, instead of the year or so of usage I'm looking at right now.
Does anyone know why the Iq might be so high?Now, it's only a project for my degree, but I'd still like to engineer it right

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Excuse the photos of the scope - I've misplaced my USB key. First shot is under full load, 5.1V @ 300mA. Second is with no load, aside from feedback resistors.