My main concern is the field of vision, it is very narrow, so tilting will inevitably be a compromise visually.
I have my scope set for about 12-14 degrees of tilt. I find no issue with FOV or depth of focus at this little bit of tilt. But I only use about 7-9x, max, for PCB work. At higher magnification, you could have more issues.
What I like about this angle is I can easily inspect IC's while soldering. Even when I use reflow soldering, I have always inspected the PCB's at an angle, having to turn the board to see all the pins. It would be great to be able to inspect all the pins from a direct overhead angle and/or even to drag solder both rows of a DIL IC without turning the pcb. But I just can't see between the pins well enough to be comfortable with that, yet.
FYI, I just measured the difference. At a 13ish degree angle, the eyepieces are about 1.5" lower, when focused on the bench top, using my 45 degree angled eyepiece microscope with 0.5" barlow. Approximately 15" over the benchtop, vs 16.5". And that is only half the equation; it's more than just the absolute height. With the tilt, I am greatly more comfortable working on a block 1.5" above the bench surface than I am with no tilt and focusing on the bench surface.
I'm a fair bit taller than the average bear, but my bench is also a bit taller than average, at 36", so I think I can say that the average user might want just a little tilt to use a Barlow lens, comfortably. I use a regular office chair and have no problem working under the scope for hours; I've never had to stop for neck or eye strain.