Metal inserts also work well. You can install them with a conical soldering iron tip.
Compared to self tappers:
+ can survive more cycles
+ smoother to turn screw (after the insert is in)
~ come in many slightly different types and sizes (with little standardisation), make sure you size your hole to match exactly what you have at hand.
- can be installed crooked
- extra part, extra step
- soldering iron tip sometimes gets jammed and then it's a pain to wiggle it out without disturbing the insert (maybe blunter tip shapes are better?)
- sometimes plastic melts somewhere you don't expect and requires drilling out
I did a test on PETG a while back and managed to get a No. 6 self tapper in and out of the same hole around 20 times before I started having issues. Albeit I do a lot of screws so maybe I was gentle and avoided cross threading, not sure.
I prefer self tappers over inserts, much faster. I'm yet to make something that a self tapper or metric + through-hole doesn't suit. I do not recommend inserting nuts, it's even fiddlier
