The Kirchoffian battery-light-switch form doesn't entirely stop being true at high frequencies, it just moves to smaller and smaller scales. At some point, that scale becomes differential, and we have to integrate Maxwell's equations to solve the problem. For most board-level problems, we can still treat a transmission line as two ports, each port being a Thevenin source of Zo, with the signal and return currents being instantaneous, at the port +/- terminals.
We then assume a whole lot of nothing happens inbetween, until the other port of the transmission line. This is a good assumption when the line is well shielded, and does not couple into space, neighbors, or itself.
If not well shielded, we can express the coupling or isolation between transmission lines, calculated in standard ways. Lines routed in parallel for some distance form a parallel-line directional coupler, and the magnitude can be calculated with quasi-static field methods (e.g., ATLC2), looked up in tables, or approximated with formulas (various calculators). At worst, we can do a full wave simulation of the geometry, and extract parameters. (Wave simulators provide ideal port connections, making this reasonable.)
The main difference to ideal transmission lines is, PCB lines are all with respect to ground, and a complete ground plane is required. We do not have ideal ports (i.e., zero common mode current). Although we can approximate them using free transmission line (e.g. twisted pair, coax) and transformer cores.
Holes in the ground plane are subject to coupling (and thus radiation) in the same way that transmission lines are subject to coupling between each other. Holes and slots act like islands and wires -- the presence or absence of conductor is reciprocal, and equivalent to some extent. Thus a trace crossing over a slot in the ground plane, couples into the slot (almost as strongly as being wired across it), and this is why slotted ground planes are generally frowned upon; when harnessed intentionally, it's a good mechanism to couple to slot lines, the Vivaldi antenna being a typical example.
Note that well-bypassed overlapping planes act together as one contiguous plane, so it's not an admonition to avoid signals crossing between power domains on a multilayer board. The slotline mode is still activated, but the wave thus launched goes under and between the planes, where it spreads out into a very low impedance, quickly becoming negligible, or eventually finding its way into bypass capacitors. Might still want to avoid crossing over sensitive analog planes, but fine for digital logic.
Tim