Used a RAM disk about 6 years ago.
It was to help with Photoshop:
The shop were printed from floor to ceiling and had a constant fade out of colour over 2.5m high, times the length of the wall.
Producing the files was really pushing it (no way to compress without getting weird VISIBLE artefacts) but printing was really hard, very much at the limit of the 4 to 8 gigs of ram we could put on a machine back them. Print files would often reach 250 to 500 megabytes, and the actual output (to the printer) be in gigabytes.
And, this particular printer (5m wide), its dedicated computer and the supplier's work flow was not mac compatible.
Anyhow, with a 8Gig RAM disk as a Photoshop primary scratch disk (and nothing else), all our troubles went away.
These things really work, I have no idea why they are not more popular.