Look at how they will act in DC conditions... if your application is DC...
in parallel the cap will act as a open circuit (no current will go though it) so you basically just have a resistor.
in series, the cap will still act as an open circuit, so what happens with the current?
for AC condtions we can kind of think the same way, what is a DC condition, essentially a very slow AC signal (where the period extends to infinity.) so with them in parallel, the current will tend to go though the resistor, in high frequencys, they will tend to go though the cap (acting as a short)