Converters get into big losses at high currents so that wouldn't be a good idea. You don't see boosters off-the-shelf that can handle big currents like that anyway. Plus it would be redundant, the motor controller handles regulation of power output regardless of input voltage. As already mentioned, just need to design things so power output meets demands when the battery is in a low state of charge.
You didn't say what kind of EV, but a 48V pack would be something typical for an eBike or eScooter. Probably would not get into hundreds of Amps with that, but still a considerable current draw at maximum outputs. In any case there are safety considerations when working with Li-Ion batteries, so yeah, not something to be careless with.
You do need to provide a mechanism to protect against over-current and over-discharge of the battery pack. These are safety considerations primarily, but otherwise severe damage to the pack can occur when limits are exceeded. As stated already, you don't want to fully discharge the pack, 20% would be liberal so you can probably go a bit lower than that.
You may want to use high drain cells over the standard ones. The capacity is somewhat lower, but they have advantages like lower operating temperatures and better longevity. Of course they also have much higher drain limits. Typically 10C compared to 2C.
These are pretty basic concepts in working with Li-Ion batteries. If you're not already aware of these things you should read up on it. This type of battery can be hazardous if not handled properly. Mainly there's a fire hazard, but in some cases packs can explode when abused causing bodily injury.