I have been running co2 lasers as my day job for 20 years. They don't cut, they burn, so if a material can be burned it can be considered laserable in a co2 machine. Many materials, like plastics, give off toxic gasses when burned. PVC releases chlorine gas, which besides being toxic is very corrosive to metals. All of this makes a very strong case for a sealed working area. I have always used a one hp high volume dust collection pump as a minimum. Unless removed quickly smoke will condense on the lens and mirrors, it will then absorb the beam energy and ruin them. Co2 is the wrong wavelength for metals. A 75 watt machine will cut a half inch of acrylic, but barely leave a mark on tin foil, though it will do a nice job engraving away the anodized coating on aluminum. None of this makes what you want to do impossible, it's just that there are a lot of things to consider.