Rats nest did both confuse me and made me take longer to do a PCB, until I maybe found a thought / technique that everybody knows, beside me:-)
I know it may not be so useable on your shown design but here it goes.
First group functions in different places or if that does not work, try to redraw your schematic on the PCB.
Then take a single group and rotate and move each component so the fewest lines do cross and so the lines goes straightest to the next component.
When each group is done, then combine them and use layer two if you need to connect between groups.
After several tries and 200 new invented curse words, should you have something useable:-)