The closest example I can think of, off hand, is old CRT TVs. I remember reports in repair magazines where a low current EHT flashover had triggered a very destructive arc across the low voltage HT mains derived supply.
Ah, but that's probably not "low current", because EHT is supported by the ~500pF capacitance of the CRT glass. Indeed, HV strikes in CRTs were a not-infrequent occurrence -- due to impurities flaking off inside the bulb, or excess gas -- and ESD protection was usually seen, usually a GDT (or three) on the socket.
I traced the signal path in a Trinitron monitor once, it's got one GDT for each cathode (the cathodes are driven with video, about 50V at ~100MHz bandwidth), and series carbon comp resistors (presumably, the lowest value possible without impairing the bandwidth, 22 ohms). The driver itself has small clamp diodes, so there's double protection. The driver is a bipolar IC, internally an emitter follower driving the output pins; it would have some capability for transient handling, but not much considering the small feature size of high voltage RF transistors used. In short: it's designed to withstand, essentially, 30kV
machine model ESD, while maintaining a 100MHz analog bandwidth -- a challenge by any means!
Tim