What's the best way to disable my sacrifice pixels so they won't work ever?
I understand your worry: the substrate is so delicate, and my fingers so sausage-y, I find it hard to reliably remove/disable a single LED without damaging the flexible strip (causing a "slight short" of the "bus bars" in the flexible strip). And that's with the cheaper 72 LEDs per meter ones, too. I mean, I can definitely get the LED off, but the problem is doing so without damaging the flexible strip and the two neighboring LEDs.
Have you considered using a paper guilliotine to cut the extra LED in half, then carefully cutting the soldered legs, leaving small "stumps" on the strip?
Unlike scissors, the guilliotine would cut (nearly) perpendicular to the strip, and wouldn't push the "bus bars" in the flexible strip around. With good sharp cutters, it is easier to cut the legs –– if visible and accessible –– than to desolder them.
You might also be able to just remove the phosphor coating, and then remove the actual LED chip(s).. but I'd worry about the leftover bond wires maybe causing some unnecessary load and/or shorts; it would leave the LED driver chip intact.
Someone like BigClive (bigclivedotcom at Youtube, bigclive.com) might know a reliable way; he plays a lot with these LED strips.