If the investigation shows that progress is impossible under these constraints, that itself is a valid conclusion.
With respect, I do believe that's where you already are with this. You just haven't accepted it yet.
You've rejected ideas to create an automated test-rig able to provide a consistent, repeatable mouse input stimulus whilst measuring response. You've rejected making measurements for noise and disturbance on power and signal lines. You've rejected the possibility to operate within a real EMI shield cage setup. I really don't know what else you think might be left that could be usefully investigated, if you still think this is an environmental effect and nothing to do with software or hardware configuration.
It is worth clarifying a few points.
1. I have exactly the same problem as O.P. (I'm only talking about him now, excluding other people with flash drives, TV, etc.)
2. We cooperate with him on solving this problem in terms of the methods, techniques, etc. used, for the same reason I say We
3. No one has abandoned the idea of creating an “automated test-rig able to provide a consistent, repeatable mouse input stimulus while measuring response” that is, an LDAT. The problem is that the OP will not be able to create it on his own without my assistance, and at the moment I personally lack sufficient experience to do so. Therefore, I created another thread on the same forum dedicated to its development. If you are willing to help in any way, I would be grateful, because this would ultimately help to create a similar device, including by the OP, which would move the research forward.
4."You've rejected making measurements for noise and disturbance on power and signal lines" - We are not against this, but let's be honest, at the moment we have not received a clear answer on how exactly this can be done, in the sense that an oscilloscope is an extremely vague concept, without recommending specific characteristics of the oscilloscope or specific models, it is empty talk, because that the concept of an "oscilloscope" includes both the conditional DSO 138 200khz for $ 10 and the Siglent SDS7804A 8GHz worth tens of thousands of dollars, so we have not received a clear definition of "good" for our purposes. If you specify specific models or parameters, we can continue to talk about this kind of measurement in detail.
5.“You’ve rejected the possibility to operate within a real EMI shield cage setup.”
We have already explained why: creating a fully shielded room is prohibitively expensive, and shielding a single PC enclosure is impossible because USB device cables and video signal cables must enter it. Therefore, this type of shielding is meaningless. If you have the willingness to provide financial support for creating the kind of shielding you are referring to, we would be grateful. With respect