[edited]
hi,
I don't get how you implemented dcdc with LTC3632(in his datasheet you input voltage to Vin pin, referenced to Gnd pin 8 and you 'take out' voltage after inductor connected on SW pin, also referenced to pin 8 ).
In your shhematic you apply between Vin and some floating virtual GND and you output between that virtual gnd and the load GND.you made an -5V for some purpose?
I don't see inductive load protection, Q1 may be the first to hit the bucket
Let's come to the point, purpose of D5 is doing what?
The tell us what voltage you have on LT3081/SET and Vout, when R31 is 0 with Ilim at max or disconnected and no load.
regards