Not really. So much depends on the noise source, what the load is connected to, the layout, the enclosure -- that a general solution will be too general to be useful.
In short, guess a reasonable starting value, and allow room for testing of different parts and values. Try all permutations of Y capacitors.
With a great amount of experience, you can anticipate which configurations are likely to be the most effective, but it's still guesswork.
There are enterprise-grade simulators that can include circuit, layout and enclosure and cabling in a full EM simulation, and produce representative EMI results without building a prototype; but the software suite to do this costs way more than a few protos and a few weeks of lab time, for most users.
Tim