The MCU doesn't care, as long as its supply is nominal.
You might care, though. That puts digital currents into the analog rail. Which is still okay as long as all digital signals are referenced to the same ground (as they must be), but, any current leaving that domain (level shifters to +/-12V?) will be kind of a problem.
Better to think of it this way: GND is GND, and the "virtual ground" op-amp is pulling the "+12" down, or the "-12" up, so as to keep the 12's balanced around GND.
Don't forget to use GND planes or pour (stitched), if this gets to a PCB.
Tim