for stuff like electrometers, maybe
when you come across the need it will be obvious
when you experiment with modified op-amp circuits, you will likely experience frustration. I recommend just getting HV op-amps if you can. The modification of a LV op amp to HV op amp is like something that you should be expect to be paid for, since in most cases it just a BOM cost reduction based on opportunity for certain parts and volumes of scale etc, unless you need something specific, which can be effected by the modification you made.