OK, solely considering *electrical* hardware, + its impact on the mechanical design, you'll need four or five wires per axis just for the stepper motors, + at least three more wires for home and limit sensors. The sensor head is going to need power, control and signal wiring.
Depending on where you locate the controller, you'll have differing numbers and lengths of moving cables. If you locate it on the sensor head, the X, Y and Z axes will have three, two and one moving cable sections respectively. Its almost the same but in the reverse order if you locate it on the frame/baseplate, except you then have three moving sections in the signal cable. However mounting it on the head makes the head *MUCH* heavier and bulkier, and you'll need bigger stepper motors and a much heavier mechanism for each axis to move it reliably. Keeping the moving mass as low as reasonably possible is therefore a good design goal. The trade-off is the need to get the sensor signal from the head to the controller.
If you are using cable chains (motion trunking), the signal cable is no problem - just put a preamp on the head and use high flexibility screened cable. If however you are trying to make it cheaper and lighter weight, you may choose to take inspiration from the control and signal wiring to the head of an inkjet or dot matrix printer, which almost invariably uses a flat flex cable in a rolling U configuration terminated to the head and a location on the chassis in the middle of the head travel. That allows a travel of slightly under twice the moving length of the cable. As the head moves, the cable rolls onto or back off a flat plate or guide half the length of the travel, with a large enough bend radius not to unduly fatigue it.
If you go for the rolling U flat flex solution, its difficult to screen the signal conductors - that would probably require a custom cable. The way round that is to amplify it to a high enough level that noise pickup is not significant and drive the cable as a balanced pair. However to get better cancellation of E fields and M fields, as a twisted pair is impractical, use four conductors in the cable, the two inner ones paralleled and the two outer ones paralleled, to get good cancellation of both E and M field pickup. I would also suggest 'clean' grounds, connected to the preamp ONLY either side of the four conductors carrying the balanced signal. For control, also use balanced signalling e.g. RS-485, but as its a digital signal, two conductors side by side should be sufficient.
Use off-the-shelf flat flex cables in standard lengths, and use padded clamps near the connectors so they don't flex at the connectors. There must be no significant movement of the cable at the clamp on the moving side, or you'll get rapid cable fatigue, so the bend of the rolling U mustn't come too close to the clamps. Design it for easy cable replacement - no complicated creased bends and with good access to the clamps and connectors.
I would also suggest a self-test mode at startup that checks the integrity of all the moving cables. The stepper conductors can be checked by sensing the current through them. The axis position sensors should be normally closed, opening at the limit and home positions. If they are open at startup, a small movement towards mid axis should result in a closed indication. If it doesn't a conductor has broken. For the signal conductors, the best bet would be to include a test signal generator circuit in the sensor head and an analog switch or reed relay to disable the vibration sensor or contact microphone. First get a baseline for the noise level with the sensor/microphone disabled, then enable the test signal and check its as expected, then disable the test signal and enable the sensor/microphone and you are good to go. For power and control to the head, if it doesn't respond to commands to activate the self test mode, either the power or control conductors are broken.