I must vote for two, and most of you will think they're mundane.
1) Hakko FR-300 desoldering gun. I was in this industry for 3+ decades before I convinced myself to spend the money on a formal desoldering gun. Now there's no going back. I don't need it every day, but when I do there is no substitute. Say goodbye to solder wick that heat-sinks the needed heat away and makes a giant solder mess. Laugh as you happily throw away those spring-loaded suction "pens" and turkey-baster-like "bulbs" whose tips seem always melted into useless shapes and are always, always too big for the target. A proper desolder gun with a hollow vacuum tip just works. Every time. I've come to using it to clean up after removing SMD devices by "vacuuming" their pads (and with a larger tip, the gun just outright removes smaller size SMD components entirely). Even my 18YO college son loves this tool like no other. It's expensive and totally worth it.
2) Hakko 951 soldering station and a wide variety of tips. I'm not brand loyal, I'm sure other stations are equally useful, but I love the ability to swap to a more appropriate tip instead of "making do" like I did for so many years. Sometimes I'm soldering 30ga wire directly to the pads of upside-down leadless SMD devices, and minutes later I'm building an associated wiring harness with 16ga cable and heavy connector contacts. There is no one-size-fits-all tip that does those two jobs equally well, and it's a joy to switch off, swap tips, switch on, and ~10 seconds later be up to temperature and have the proper tip for each job. I just bought two more tips yesterday, in fact, knowing that I'm heading into some very fine SMD breadboarding soon.
I have lots more tools that are valuable, but for (1) making a formerly difficult job almost infinitely easier and better, and (2) doing each type of soldering properly instead of trying to fudge everything with a one-size-fits-none single tip, these two (types of) tools really stand out in comparison to how their respective jobs were done before I owned both of them.