It may be possible. I had a look at the LTC3780 datasheet, and the voltage adjust seems to be done with a voltage divider, so it may be easy to change the pot value by changing the fixed resistor in the divider.
https://www.analog.com/media/en/technical-documentation/data-sheets/LTC3780.pdfIf you look at page 21 it gives the equation for working out the voltage divider for the circuit on page 26 (R1, R2). So if you find the resistor(s) connected to the voltage pot, you should be able to find out which ones to change. It is entirely possible that they just used the pot across the output, and the wiper to the chip, in which case you could just swap the pot for any value without the need to change anything else, but you do want as high a resistance as possible, as it would be across the supply.
The current might be a little more problematic, as i'm not sure the mechanism it is using to control that. I suspect it may be a pot connected to the I
TH and fed from a voltage reference somewhere, so you might need to trace out its circuit before you get suggestions to change it.