The input capacitance is is measured between the the gate and source and drain shorted together.
The total gate charge is the amount of charge which needs to flow into the gate to turn the MOSFET on. It's greater than what one would calculate using the input capacitance, because the gate to drain capacitance is increased due to the Miller effect, when the MOSFET starts to turn on.
See page 8 of the poper linked below:
https://www.infineon.com/dgdl/mosfet.pdf?fileId=5546d462533600a4015357444e913f4fWhat are you using to drive the MOSFET?
The switching losses can be minimised by choosing a device with as lower gate charge as possible, whilst still having a high enough voltage rating an low enough on resistance to minimise the on loss. This isn't too difficult, just don't oversize the MOSFET too much and it will be fine.