I would not break off the tab. Preventing the pot body from turning is not really a "nicety" in my book. It is a necessity, especially for PCB mounted ones.
If your front panel is too thin and/or you don't want to try putting a hole in the back of it, then I would suggest a secondary panel between the front panel and the pot, with the appropriate holes drilled right through it. To stop this panel from rotating, all you need is another pot, switch, etc mounted on the front panel and/or have at least one edge of it resting against the body of the enclosure.
This approach can be taken further, in that you can have all the pots, switches, etc. mounted to such a panel which is part of the chassis and just have the front panel as a "dress" panel, having nothing mounted on it - just the labels, logo and livery. My HP5381A frequency counter does exactly this and the concept is quite common.