You have plenty of room to put the RESET and WAKEUP buttons to the left of the other buttons. Move the IC1 more to the left, trace to SW3 can be routed above the bootstrap button and then between the other button...
You're using a 1117 regulator, probably the kind that's stable with ceramic capacitors on the output but who knows if some person copies your design and doesn't know 1117 aren't all the same... maybe consider using something else, personally don't like to use them.
Nothing really wrong with it, but that trace going from RV2 to the bottom trace at that angle bothers me. Maybe it could go directly down to that 3.3v pad instead of cutting over the silkscreen or whatever?