Just a beginner with QFP myeslf, and reflecting on my many failures before giving up and getting TSSOP versions, but I wonder if one of the major problems when hand-soldering them is that you don't get an even amount of solder on each pad? Some will have plenty of solder and others... not so much. So when you heat the chip up and even get it to stick in place after the solder melts, you still might end up with unconnected pins. Or at least, I almost always did

The tweezers probably do help in that area though, as they will squish some of the (hopefully not egregious) excess solder out and make sure that all pins get at least some solder bonding the chip to the pad when it cools. I wasn't trying the tweezers at the time other than to hold it in place, so that's just my speculation.
The other issue is when it has the middle pad, because it requires "just enough" solder. Not enough, and the pad can't act as a good heat sink. Too much, and the chip just floats on the middle pad.