50 ohm single resistance became 100 ohm total, is this not twice the resistance, twice the work for the cell ?
Nope, it's actually half the "work" (the correct term here would be "power", as "work" is actually a technical thing and basically means energy - power is work over time) for the cell. I assume you're familiar with Ohm's Law at this point, yeah? So, voltage equals current times resistance: V = I*R. Plug in two values and you get the third.
If you connect a 50 ohm resistance to a 50 volt source, you get a current of 1 A: 50 = 50*I, the current, "I", can only be 1 A. If you connect a 100 ohm resistance instead, you get 50 = 100*I, I = 0.5 A...
(I guess I can work out the wattage knowing the voltage of the cell at that point and the resistance value of the resistor ?)
...at which point you can use whichever equation you prefer: P = R*I², P = V*I, P = V²/R to work out the power. For the first case, you're draining 1 A from a 50 V source, and that's a power of 50 W. Alternatively, that's a 50 ohm resistance connected to a 50 V source, and that's the same 50²/50 = 50 W, you get the idea.
For the second case, you're draining 0.5 A from a 50V source, so that's a power of 25 W. With greater resistance you get a lesser current, so the battery is giving out less power. Consider free air, with a resistance that you could call infinite for these purposes: infinite resistance, zero current, therefore zero power. If greater resistance meant greater power/stress/"work" from the battery, then batteries wouldn't hold a charge, just from standing there, since there would be infinite resistance from the air between their terminals, which would cause them to "work infinitely hard", so to speak, which in turn would immediately cause them to be depleted.
It might help a bit to think of a sometimes criticized, yet close enough for argument's sake, analogy: a battery is a water reservoir, the wires are pipes, voltage is the pressure, current is the water flow, resistance is a restriction to the water flow. The reservoir doesn't "work harder" when there's a restriction, there's just less water flowing through the pipes.