If you want really low leakage use caps rated at over 250V, 400V or 630v film units are guaranteed to have a very low leakage at rated voltage, and at CMOS levels it is pretty close to being equal to the PCB surface leakage. 16V ceramic units can have a quite high leakage, and with the lovely voltage dependence of capacitance timing will be pretty poor with supply voltage variations. If you are going to use ceramic use 100V units, though they will be a lot bigger than 16V units