Drill holes are normally about 0.05-0.1mm larger in diameter than the pin going through the hole, but for easier insertion and soldering you can make them 0.2-0.4mm larger. 0.8mm works well for almost all through hole resistors below 1watt, all DIP IC pins, 1N4148s, TO92 transistors and the like. Use 1.0mm for header pins, TO220 packages, 1N4001, etc. and 1.3mm for terminal block connectors.
Rule of thumb with pads is make them as large as you possibly can (within reason). Ensure adequate spacing between adjacent pads - 8-10 thou is good - but otherwise make them as big as you can. Same goes for tracks, make them as fat as possible at all times. Rounded finger pads are good for DIP ICs because they give you more surface area for solder contact while still allowing you to easily route a track between pins.
Bigger pads also give better adhesion to the board substrate, so if you have any large and heavy components (big psu caps) it's a good idea to give them extra big pads to ensure the mass and leverage of the component doesn't break the pad off the board when your board is chucked about.
I usually specify drill size in mm but work with thou for pad/track sizes.